Corresponding author*, Co-first author'
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Zhong Z, Mu X, Lang H, Wang Y, Jiang Y, Liu Y, Zeng Q, Xia S, Zhang B, Wang Z, Wang X*, Zheng H*
Gut-symbiont derived anandamide promotes reward learning in honeybees by activating the endocannabinoid system
2024 Cell Host & Microbe 32:1–15 DOI
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Lang H, Liu Y, Duan H, Zhang W, Hu X, Zheng H*
Identification of peptides from honeybee gut symbionts as potential antimicrobial agents against Melissococcus plutonius
2023 Nat Commun 14:7650 DOI
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Lang H, Wang H, Wang HQ, Zhong Z, Xie X, Zhang W, Guo J, Meng L, Hu X, Zhang X, Zheng H*
Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees
2023 Nat Commun 14:2778 DOI
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Zhang Z, Mu X, Cao Q, Shi Y, Hu X, Zheng H*
Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism
2022 Nat Commun 13:2037 DOI
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Zheng H*, Perreau JJ. Powell EJ, Han B, Zhang Z, Kwong WK, Tringe SG, Moran NA*
Division of labor in honey bee gut microbiota for plant polysaccharide digestion
2019 PNAS 116:25909–25916 DOI
Highlighted in Nat Rev Microbiol: Microbiome;
Blog on JGI: Honey Bee Gut Microbiota Divvy Up Dinner;
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Zheng H*, Powell JE, Steele MI, Dietrich C, Moran NA*
Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling
2017 PNAS 114:4775–4780 DOI F1000 Recommended
All Publications
63. Zhong Z, Mu X, Lang H, Wang Y, Jiang Y, Liu Y, Zeng Q, Xia S, Zhang B, Wang Z, Wang X*, Zheng H*
Gut-symbiont derived anandamide promotes reward learning in honeybees by activating the endocannabinoid system
2024 Cell Host & Microbe 32:1–15 DOI
62. Qi Y, Wang C, Lang H, Wang Y, Wang X*, Zheng H*, Lu Y*
Liposome-based RNAi delivery in honeybee for inhibiting parasite Nosema ceranae
2024 Synth Syst Biotechnol 9:853–860 DOI
61. Wang H, Zheng H*
Commentary: From buzz to brilliance: How bees shape social learning and cultural evolution
2024 Integr Zool DOI
60. Meng Y, Zhang X, Zhai Y, Li Y, Shao Z, Liu S, Zhang C, Xing X, Zheng H*
Identification of the mutual gliding locus as a factor for gut colonization in non-native bee hosts using the ARTP mutagenesis
2024 Microbiome 12:93 DOI
59. Zhang Z, Mu X, Cao Q, Zhai Y, Zheng L, Liu Y, Zheng H, Zhang X*
Antibiotic exposure alters the honeybee gut microbiota and may interfere with the honeybee behavioral caste transition
2024 Insect Sci in press DOI
58. Yang C, Hu J, Su Q, Zhang Z, Du Y, Wang J, Sun H,... Zheng H, Zhou X*, Zhang X*
Review: A review on recent taxonomic updates of gut bacteria associated with social bees, with a curated genomic reference database
2024 Insect Sci in press DOI
57. Liu H, Mu X, Fan R, Chen J, Ma J, Meng L, Hu X, Zheng H, Liu S, Wang X*
Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain
Food Sci Hum Wellness in press
56. Liu H, Zheng H, Zhang J, Chen F, Hu X, Wang X*
Review: Review of the toxic effects and health functions of arecoline on multiple organ systems
2024 Food Innov Adv 3:31-41 DOI
55. Zhu L, Wang K, Wu X*, Zheng H, Liao X
Association of specific gut microbiota with polyethylene microplastics caused gut dysbiosis and increased susceptibility to opportunistic pathogens in honeybees
2024 Sci Total Environ 918:170642 DOI
54. Zhang W, Sun C, Lang H, Wang J, Li X, Guo J*, Zhang Z*, Zheng H*
Toll receptor ligand Spätzle 4 responses to the highly pathogenic Enterococcus faecalis from Varroa mites in honeybees
2023 PLoS Pathog 19:e1011897 DOI
53. Lang H, Liu Y, Duan H, Zhang W, Hu X, Zheng H*
Identification of peptides from honeybee gut symbionts as potential antimicrobial agents against Melissococcus plutonius
2023 Nat Commun 14:7650 DOI
52. Li Y, Zhang Y, Luo X, Meng Y, Zhong Z, Zheng H*, Yang Y*
The fecal microbiota from children with Autism impact gut metabolism and learning and memory abilities of honeybees
2023 Front Microbiol 14:1278162 DOI
51. Chen J, Mu X, Liu H, Yong Q, Ouyang X, Liu Y, Zheng L, Chen H, Zhai Y, Ma J, Meng L, Liu S*, Zheng H*
Rotenone impairs brain glial energetics and locomotor behavior in bumblebees
2024 Sci Total Environ 907:167870 DOI
50. Yu Q', Liu Y', Liu S', Li S, Zhang Q, Zhai Y, Zheng L, Zheng H, Zhai Y*, Wang X*
Lactobacillus melliventris promoted the hive productivity and immune functionality in Bombus terrestris performance in the greenhouse
2024 Insect Sci 31:911–926 DOI
49. Wang X, Zhai Y, Zheng H*
Review: Deciphering the cellular heterogeneity of the insect brain with single-cell RNA sequencing
2024 Insect Sci 31:314–327 DOI
48. Wang X, Cheng X, Liu H, Mu X, Zheng H*
Review: Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing
2024 Food Sci Hum Wellness 13:75–89 DOI
47. Lang H, Wang H, Wang HQ, Zhong Z, Xie X, Zhang W, Guo J, Meng L, Hu X, Zhang X, Zheng H*
Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees
2023 Nat Commun 14:2778 DOI
46. Cheng X', Wang C', Liu D', Liao Y, Wang B, Zhang X, Zheng H, Lu Y*
Dynamic artificial cells by swarm nanorobotics and synthetic life chemistry
2023 Sci China Mater 66:2090–2099 DOI
45. Cheng X', Wang C', Yang J', Liu D, Liao Y, Wang B, Han S, Zhang X, Zheng H*, Lu Y*
Nanotransducer-enabled wireless spatiotemporal tuning of engineered bacteria in bumblebee
2023 Small 19:2370288 DOI
44. Sun H, Li H, Zhang X, Liu Y, Chen H, Zheng L, Zhai Y, Zheng H*
Review: The honeybee gut resistome and its role in antibiotic resistance dissemination
2023 Integr Zool 18:1014-1026 DOI
43. Wang J, Lang H, Zhang W, Zhai Y, Zheng L, Chen H, Liu Y, Zheng H*
Stably transmitted defined microbial community in honeybees preserves Hafnia alvei inhibition by regulating immune system
2022 Front Microbiol 13:1074153 DOI
42. Liu Y, Chen J, Lang H, Zheng H*
Bartonella choladocola sp. nov. and Bartonella apihabitans sp. nov., two novel species isolated from honey bee gut
2022 Sys Appl Microbiol 45:126372 DOI
41. Chang R, Chen J, Zhong Z, Li Y, Wu K, Zheng H*, Yang Y*
Inflammatory bowel disease-associated Escherichia coli strain LF82 in the damage of gut and cognition of honeybees
2022 Front Cell Infect Microbiol 12:983169 DOI
40. Meng Y, Li S, Zhang C*, Zheng H*
Strain-level profiling with picodroplet microfluidic cultivation reveals host-specific adaption of honeybee gut symbionts
2022 Microbiome 10:140 DOI
39. Yang C, Su Q, Tang M, Luo S, Zheng H, Zhang X*, Zhou X*
Amplicon sequencing of single-copy protein-coding genes reveals accurate diversity for sequence-discrete microbiome populations
2022 Microbiol Spectr 10:e02105-21 DOI
38. Zhang Q', Wang Q', Zhai Y, Zheng H*, Wang X*
Impacts of imidacloprid and flupyradifurone insecticides on the gut microbiota of Bombus terrestris
2022 Agriculture 12:389 DOI
37. Wang K', Zhu L', Rao L, Zhao L, Wang Y, Wu X*, Zheng H*, Liao X
Nano- and micro-polystyrene plastics disturb gut microbiota and intestinal immune system in honeybee
2022 Sci Total Environ 842:156819 DOI
36. Wang X, Qi Y, Zheng H*
Review: Dietary polyphenol, gut microbiota, and health benefits
2022 Antioxidants 11:1212 DOI
35. Zhang Z, Zheng H*
Review: Bumblebees with the socially transmitted microbiome: a novel model organism for gut microbiota research
2022 Insect Sci 29:958-976 DOI
34. Sun H, Mu X, Zhang K, Lang H, Su Q, Li X, Zhou X, Zhang X*, Zheng H*
Geographical resistome profiling in the honeybee microbiome reveals resistance gene transfer conferred by mobilizable plasmids
2022 Microbiome 10:69 DOI
33. Zhang Z, Mu X, Cao Q, Shi Y, Hu X, Zheng H*
Honeybee gut Lactobacillus modulates host learning and memory behaviors via regulating tryptophan metabolism
2022 Nat Commun 13:2037 DOI
32. Zhang Z, Mu X, Shi Y, Zheng H*
Distinct roles of honeybee gut bacteria on host metabolism and neurological process
2022 Microbiol Spectr 10:e02438-21 DOI
31. Li L, Pan H, Pang G, Lang H, Shen Y, Sun T, Zhang Y, Liu J, Chang J, Kang J*, Zheng H*, Wang H*
Precise thermal regulation of engineered bacteria secretion for breast cancer treatment in vivo
2022 ACS Synth Biol 11:1167–1177 DOI
30. Zhang W', Zhang X', Su Q, Tang M, Zheng H, Zhou X*
Genomic features underlying the evolutionary transitions of Apibacter to honey bee gut symbionts
2022 Insect Sci 29:259-275 DOI
29. Wang X, Zhong Z, Chen X, Hong Z, Lin W, Mu X, Hu X, Zheng H*
High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee
2021 Int J Mol Sci 22:834 DOI
28. Lang H, Duan H, Wang J, Zhang W, Guo J, Zhang X, Hu X, Zheng H*
Specific strains of honeybee gut Lactobacillus stimulate host immune system to protect against pathogenic Hafnia alvei
2021 Microbiol Spectr 10:e01896-21DOI
27. Su Q', Wang Q', Mu X, Chen H, Meng Y, Zhang X, Zheng L, Hu X, Zhai Y*, Zheng H*
Strain-level analysis reveals the vertical microbial transmission during the life cycle of bumblebee
2021 Microbiome 9:216 DOI
26. Wu J', Lang H', Mu X, Zhang Z, Su Q, Hu X, Zheng H*
Honey bee genetics shape the strain-level structure of gut microbiota in social transmission
2021 Microbiome 9:225 DOI
25. Jieteng Chen, Jieni Wang, Hao Zheng*
Characterization of Bifidobacterium apousia sp. nov., Bifidobacterium choladohabitans sp. nov., and Bifidobacterium polysaccharolyticum sp. nov., three novel species of the genus Bifidobacterium from honey bee gut
2021 Sys Appl Microbiol 44:126247 DOI
24. Yulin Song, Vincent Hervé, Renate Radek, Fabienne Pfeiffer, Hao Zheng, Andreas Brune*
Characterization and phylogenomic analysis of Breznakiella homolactica gen. nov. sp. nov. indicate that termite gut treponemes evolved from non-acetogenic spirochetes in cockroaches
2021 Env Microbiol 23:4228–4245 DOI
23. Zijing Zhang, Mingfei Huang, Lifei Qiu, Ruihao Song, Zixuan Zhang, Yiwen Ding, Xin Zhou, Xue Zhang*, Hao Zheng*
Diversity and functional analysis of Chinese bumblebee gut microbiota reveal the metabolic niche and antibiotic resistance variation of Gilliamella
2020 Insect Sci 28:302-314 DOI
22. Xue Zhang, Daniel E. Deatherage, Hao Zheng, Stratton J. Georgoulis, Jeffery E. Barrick*
Evolution of satellite plasmids can prolong the maintenance of newly acquired accessory genes in bacteria
2019 Nat Commun 10:5809 DOI
21. Hao Zheng*, Julie Perreau, J. Elijah Powell, Benfeng Han, Zijing Zhang, Waldan K. Kwong, Susannah G. Tringe, Nancy A. Moran*
Division of labor in honey bee gut microbiota for plant polysaccharide digestion
2019 Proc Natl Acad Sci USA 116:25909–25916 DOI
Highlighted in Nat Rev Microbiol: Microbiome
Blog on JGI: Honey Bee Gut Microbiota Divvy Up Dinner
20. Xiaofei Wang, Xue Zhang, Zijing Zhang, Haoyu Lang, Hao Zheng*
Review: Honey bee as a model organism to study gut microbiota and diseases
2019 Drug Discovery Today: Disease Models 28:35–42 DOI
19. Jieni Wang, Qinzhi Su, Xue Zhang*, Chenyi Li, Shiqi Luo, Xin Zhou, Hao Zheng*
Entomomonas moraniae gen. nov., sp. nov., a member of the family Pseudomonadaceae isolated from Asian honey bee gut, possesses a highly reduced genome
2019 Int J Syst Evol Microbiol Available online DOI
18. 张雪, 李兴安, 苏秦之, 曹棋钠, 李晨伊, 牛庆生*, 郑 浩*
综述: 用于蜜蜂和熊蜂肠道微生物分类的细菌16S rRNA数据库优化
2019 生物多样性 27:557–566 DOI
17. Zheng H, Steele MI, Leonard SP, Motta EVS, Moran NA*
Review: Honey bees as models for gut microbiota research
2018 Lab Animal 47:317–325 DOI
16. 李晨伊, 周欣, 郑浩*
综述: 蜜蜂肠道微生物群落研究进展
2018 微生物学报 58:1016–1024 (Review in Chinese) DOI
15. Zheng H*, Powell JE, Steele MI, Dietrich C, Moran NA*
Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling
2017 Proc Natl Acad Sci USA 114:4775–4780 PubMed DOI
14. Zheng H, Dietrich C, Brune A*
Genome analysis of Endomicrobium proavitum suggests loss and gain of relevant functions during the evolution of intracellular symbionts
2017 Appl Environ Microbiol 83:e00656-17 PubMed DOI
13. Kwong WK*, Zheng H, Moran NA
Convergent evolution of a modified, acetate-driven TCA cycle in bacteria
2017 Nat Microbiol 2:17067 PubMed DOI
12. Mikaelyan A, Thompson CL, Meuser K, Zheng H, Rani P, Plarre R, Brune A*
High-resolution phylogenetic analysis of Endomicrobia reveals multiple acquisitions of endosymbiotic lineages by termite gut flagellates
2017 Environ Microbiol Rep 9:477–483 PubMed DOI
11. Zheng H', Dietrich C', Brune A*
Restriction-modification systems as mobile genetic elements in the evolution of an intracellular symbiont
2016 Mol Biol Evol 33:721–725 PubMed DOI
10. Zheng H*, Nishida A, Kwong W, Koch H, Engel P, Steele MI, Moran NA
Metabolism of toxic sugars by strains of the bee gut symbiont Gilliamella apicola
2016 mBio 7:e01326-16 PubMed DOI
9. Zheng H, Dietrich C, Radek R, Brune A*
Endomicrobium proavitum, the first isolate of Endomicrobia class. nov. (phylum Elusimicrobia) – an ultramicrobacterium with an unusual cell cycle that fixes nitrogen with a Group IV nitrogenase
2016 Environ Microbiol 18:191–204 PubMed DOI
8. Zheng H, Dietrich C, Thompson CL, Brune A*
Population structure of Endomicrobia in single host cells of termite gut flagellates (Trichonympha spp.)
2015 Microbes Environ 30:92–98 PubMed DOI
7. Zheng H, Brune A*
Complete genome sequence of Endomicrobium proavitum, a free-living relative of the intracellular symbionts of termite gut flagellates (phylum Elusimicrobia)
2015 Genome Announc 3:e00679-15 PubMed DOI
6. Zheng H', Bodington D', Zhang C, Tanji Y, Miyanaga K, Hongoh Y, Xing XH*
Comprehensive phylogenetic diversity of [FeFe]-hydrogenase genes in termite gut microbiota
2013 Microbes Environ 28:491–494 PubMed DOI
5. Zheng H, Zhang C, Lu Y, Jiang PX, Xing XH*
Alteration of anaerobic metabolism in Escherichia coli for enhanced hydrogen production by heterologous expression of hydrogenase genes originating from the Synechocystis sp.
2012 Biochem Eng J 60:81–86 DOI
4. Liu Z, Lv FX, Zheng H, Zhang C, Wei F, Xing XH*
Enhanced hydrogen production in a UASB reactor by retaining microbial consortium onto carbon nanotubes (CNTs)
2012 Int J Hydrogen Energ 37:10619–10626 DOI
3. Feng Q, Wang YX, Wang TM, Zheng H, Chu LB, Zhang C, Chen HZ, Kong XQ, Xing XH*
Effects of packing rates of cubic-shaped polyurethane foam carriers on the microbial community and the removal of organics and nitrogen in moving bed biofilm reactors
2012 Bioresource Technol 117:201–207 PubMed DOI
2. Yan ST, Zheng H, Li A, Zhang X, Xing XH*, Chu LB, Ding GJ, Sun XL, Jurcik B
Systematic analysis of biochemical performance and the microbial community of an activated sludge process using ozone-treated sludge for sludge reduction
2009 Bioresour Technol 100:5002–5009 PubMed DOI
1. Yan ST, Li A, Zheng H, Luo MF, Xing XH*
Effects of ionic surfactants on bacterial luciferase and α-amylase
2009 Chinese J Chem Eng 17:829–834 DOI